马春红

   |    2015年9月10日  |   文章  |    0 条评论  |    7504

马春红(1970.11–),博士  教授、博士生导师。

 

国家自然科学基金杰出青年基金、中组部“万人计划”领军人才、教育部“新世纪优秀人才支持计划”、霍英东基金会高等院校青年教师基金、山东省杰出青年基金获得者,全国三八红旗手。

 

工作经历:

2018.1-至今 山东大学,齐鲁医学院,副院长,教授

2006/12-2017.12 山东大学,医学院,副院长,教授

2004/2-2005/2 美国肯塔基大学免疫学、微生物学与分子遗传学系,访问学者

2003/9-至今 山东大学,医学院免疫学系,教授

2001/1-2003/9山东大学,医学院免疫学研究所,副教授

1997/1-1999/12原山东医科大学,基础医学部微生物学与免疫学教研室,讲师

1994/7-1996/12原山东医科大学,基础医学部微生物学与免疫学教研室,助教

 

研究方向:

1.局部免疫微环境与肝病;

2.HBV 感染慢性化及恶性进展机制;

3.代谢与肝病。

 

承担或完成国家级课题:

  1. 国家重点研发计划“政府间国际科技创新合作重点专项”(中日政府间科技合作联委会联合研究项目),2016YFE0127000,射频消融改造肿瘤相关巨噬细胞在肝癌免疫治疗中的意义,2017/01-2019/12,284万元,在研,主持
  2. 国家自然科学基金重大研究计划集成项目,91529305,乙肝恶性转化过程中病毒变异与炎症网络的交互作用机制,2016/01-2018/12,249万元,在研,参加
  3. 国家自然科学基金杰出青年基金,81425012,HBV 感染、免疫与肝病,2015/01-2019/12,400万元,在研,主持,
  4. 国家自然科学基金面上项目,新型抑癌基因ZHX2调节脂质代谢参与非酒精性脂肪肝的作用研究81370527,2014/01-2017/12,70万元,结题,主持
  5. 国家自然科学基金重大研究计划培育项目,Tim-3介导的NK及其调节网络异常在非可控性乙型肝炎向肝癌恶性转化进程中的作用,91129704,2012/01-2014/12,60万元,结题,主持
  6. 国家自然科学基金面上项目,HBV上调Foxp3表达促进肝癌细胞恶性增殖和免疫逃逸的分子机制研究,81172353,2012/01-2015/12,63万元,结题,主持
  7. 国家自然科学基金面上项目,Tim-3在HBV感染所致CD8+T细胞功能失调中的作用及机制研究,30972753,2010/01-2012/12,30万元,结题,主持
  8. 国家自然科学基金面上项目,新型转录抑制因子ZHX2对肝癌细胞中AFP表达调控的分子机制研究,30670966,2007/01-2009/12,27万元,结题,主持
  9. 国家自然科学基金项目面上项目,乙肝病毒羧基末端截短的pres2/s编码蛋白(MHBst)对端粒酶的反式激活作用及其分子机制研究,30471525,2005/01-2007/12,20万元,结题,主持

 

发表代表性论文:

  1. Zhang H, Song Y, Yang H, Liu Z, Gao L, Liang X**, Ma C**. Tumor cell-intrinsic Tim- 3 promotes liver cancer via NF-κB/IL-6/STAT3 axis. Oncogene. 2018 Feb 16. doi:10.1038/s41388-018-0140-4.
  2. Zhao D, Guo M, Liu B, Lin Q, Xie T, Zhang Q, Jia X, Shu Q, Liang X, Gao L**, Ma C**. Frontline Science: Tim-3-mediated dysfunctional engulfment of apoptotic cells in SLE. J Leukoc Biol. 2017 Dec;102(6):1313-1322.
  3. Liu Y, Cheng Y, Xu Y, Wang Z, Du X, Li C, Peng J, Gao L, Liang X, Ma C. * Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated antitumor function and indicates poor prognosis in digestive cancers.Oncogene. 2017 Nov 2;36(44):6143-6153. doi: 10.1038/onc.2017.209.
  4. Liu Y, Gao LF, Liang XH, Ma CH.*Role of Tim-3 in hepatitis B virus infection: An overview. World J Gastroenterol. 2016 Feb 21;22(7):2294-303.
  5. Wan F, Gao L, Lu Y, Ma H, Wang H, Liang X, Wang Y**, Ma C.**Proliferation andosteo/odontogenic differentiation of stem cells from apical papilla regulated by Zinc fingers and homeoboxes 2: An in vitro study. Biochem Biophys Res Commun. 2016 Jan 15;469(3):599-605.
  6. Yan W, Liu X, Ma H, Zhang H, Song X, Gao L, Liang X, Ma C.* Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages.Gut. 2015 Oct;64(10):1593-604.
  7. Zhang Z, Liang X, Gao L, Ma H, Liu X, Pan Y, Yan W, Shan H, Wang Z, Chen YH**, Ma C**.TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells. Oncogene. 2015 May 14;34(20):2566-74.
  8. Zhang X, Gao L, Liang X, Guo M, Wang R, Pan Y, Liu P, Zhang F, Guo C, Zhu F, Qu C, Ma C*.HBV preS2 transcactivates FOXP3 expression in malignant hepatocytes. Liver Int. 2015 Mar;35(3):1087-94.
  9. Luan F, Liu P, Ma H, Yue X, Liu J, Gao L, Liang X, Ma C*.Reduced nucleic ZHX2 involves in oncogenic activation of glypican 3 in human hepatocellular carcinoma. Int J Biochem Cell Biol. 2014 Sep 6;55C:129-135.
  10. Liu X, You J, Zhao D, Guo M, Pan Y, Gao L, Liang X**, Ma C**.Dysregulated expression of T cell immunoglobulin and mucin domain 3 is associated with the disease severity and the outcome of patients with spontaneous intracerebral hemorrhage.Clin Biochem. 2013 Oct;46(15):1502-8.
  11. Zhuang X, Zhang X, Xia X, Zhang C, Liang X, Gao L, Zhang X, Ma C.* Ectopic Expression of TIM-3 in Lung Cancers. Am J Clin Pathol. 2012 Jun;137(6):978-85.
  12. Yue X, Zhang Z, Liang X, Gao L, Zhang X, Zhao D, Liu X, Ma H, Guo M, Spear BT, Gong Y, Ma C.* Zinc Fingers and Homeoboxes 2 Inhibits Cell Proliferation and Represses Cyclin A and Cyclin E expression. Gastroenterology. 2012 Jun;142(7):1559-1570.e2.
  13. Hou N, Zhao D, Liu Y, Gao L, Liang X, Liu X, Gai X, Zhang X, Zhu F, Ni M, Zhang Y, Sun W, Ma C. *. Increased expression of T cell immunoglobulin- and mucin-domain-containing molecule-3 on NK cells in atherogenesis. Atherosclerosis. 2012 May;222(1):67-73.
  14. Zhao D, Hou N, Cui M, Liu Y, Liang X, Zhuang X, Zhang Y, Zhang L, Yin D, Gao L, Zhang Y, Ma C*. Increased T cell Immunoglobulin and Mucin Domain 3 Positively Correlate with Systemic IL-17 and TNF-α Level in the Acute Phase of Ischemic Stroke. J Clin Immunol. 2011 Aug;31(4):719-27.
  15. Liu Y, Shu Q, Gao L, Hou N, Zhao D, Liu X, Zhang X, Xu L, Yue X, Zhu F, Guo C, Liang X, Ma C*. Increased Tim-3 expression on peripheral lymphocytes from patients with rheumatoid arthritis negatively correlates with disease activity. Clin Immunol. 2010 Nov;137(2):288-95.
  16. Liu H, Shi W, Luan F, Xu S, Yang F, Sun W, Liu J, Ma C.*, Hepatitis B virus X protein upregulates transcriptional activation of human telomerase reverse transcriptase. Virus Genes. 2010 Apr;40(2):174-82.
  17. Ju Y, Hou N, Meng J, Wang X, Zhang X, Zhao D, Liu Y, Zhu F, Zhang L, Sun W, Liang X, Gao L, Ma C*, T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B. J Hepatol. 2010 Mar;52(3):322-9.
  18. Luan F, Liu H, Gao L, Liu J, Sun Z, Ju Y, Hou N, Guo C, Liang X, Zhang L, Sun W, Ma C. *,Hepatitis B virus protein preS2 potentially promotes HCC development via its transcriptional activation of hTERT. Gut. 2009 Nov;58(11):1528-37.
  19. Zhijin Chen, Dexin Yu, Shaojie Wang, Na Zhang*, Chunhong Ma, Zaijun Lu*. Biocompatible nanocomplexes for molecular targeted MRI contrast agent. Nanoscale Res lett., 2009,4: 618-626
  20. Ju Y, Hou N, Zhang XN, Zhao D, Liu Y, Wang JJ, Luan F, Shi W, Zhu FL, Sun WS, Zhang LN, Gao CJ, Gao LF, Liang XH, Ma CH.* Blockade of Tim-3 Pathway Ameliorates Interferon-gamma Production from Hepatic CD8(+) T Cells in a Mouse Model of Hepatitis B Virus Infection. Cell Mol Immunol. 2009 Feb;6(1):35-43.
  21. Shen H, Luan F, Liu H, Gao L, Liang X, Zhang L, Sun W, Ma C*.ZHX2 is a Repressor of Alpha-fetoprotein Expression in Human Hepatoma Cell Lines. J Cell Mol Med. 2008 Dec; 12(6B):2772-80.
  22. Wang Y, Meng J, Wang X, Liu S, Shu Q, Gao L, Ju Y, Zhang L, Sun W, Ma C*.Expression of human TIM-1 and TIM-3 on lymphocytes from systemic lupus erythematosus patients. Scand J Immunol. 2008 Jan;67(1):63-70
  23. Liu H, Luan F, Ju Y, Shen H, Gao L, Wang X, Liu S, Zhang L, Sun W, Ma C*. In vitro transfection of the hepatitis B virus PreS2 gene into the human hepatocarcinoma cell line HepG2 induces upregulation of human telomerase reverse transcriptase. Biochem Biophys Res Commun. 2007 Apr 6;355(2):379-84

 

科研奖励

  • 乙肝病毒及免疫微环境参与慢性炎症和恶性转化的机制研究, 中华人民共和国国家教育部, 自然科学, 省部一等奖, 2017,马春红; 梁晓红; 高立芬; 鞠瑛; 栾芳; 岳学田; 闫文江; 刘晓; 杜鹃; 侯楠; 张真瑜; 庄学伟; 申红玉; 刘莹)

 

学术兼职:

  • 教育部实验畸形学重点实验室,主任
  • 国家自然基金委会审专家
  • 国家留学基金委评审专家
  • 中华医学会微生物与免疫学分会青年委员会委员
  • 山东免疫学会常务理事

 

联系方式:

E-mail:machunhong@sdu.edu.cn

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